Chemotherapeutic results in small cell lung cancer.

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Small cell lung cancer (SCLC) is a distinct and well-reproducible histopathological entity (Hirsch et al. 1982). Besides morphological criteria, SCLC is distinguished from other cell types by ultrastructural, endocrine, cytogenetic, cell-kinetic, and clinical findings (Gropp et al. 1980; Hattori et al. 1972; Whang-Peng et al. 1982). The high labeling index (Muggia et al. 1974; Pettengill et al. 1980) and short doubling time (Straus 1974; Weiss et al. 1970) are manifested clinically by fast growth, rapid onset of signs and symptoms, and a tendency toward early and widespread dissemination (Hansen et al. 1978; Muggia and Chevru 1974). Accordingly, the median survival time from diagnosis without treatment is 2.8 months, with only 4.2% of patients still alive at 1 year (Hyde et al. 1965; Zelen 1973).KeywordsSmall Cell Lung CancerSmall Cell CarcinomaSmall Cell Lung CarcinomaBronchogenic CarcinomaProphylactic Cranial IrradiationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.