Abstract
The Mediterranean diet (MD) has proven itself protective against many diseases, including cancer. A Mediterranean diet comprises whole grains, vegetables, fruits, fish, extra virgin olive oil, red wine, and legumes. Foods studied within this diet contain high levels of antioxidants and anti-inflammatory compounds. The diversity of healthy foods and numerous nutritional benefits maximizes chemoprotection with a variety of protective substances. The Mediterranean diet has high concentrations of polyphenols and offers chemoprotective properties including carotenoids, vitamins, and flavonoids. These phytochemicals contain antioxidant properties that prevent DNA damage. High levels of omega-3 within this diet have been studied to slow down cancer development, cancer cell proliferation, angiogenesis, survival, inflammation, and metastasis. The consumption of extra virgin olive oil has been found to lower the incidence of dermatological diseases. Wine-making byproducts inhibit the growth of A431 skin cancer cells and induce cytotoxicity and apoptosis only to cells with morphological changes. Our review addresses the chemoprotective properties of how a Mediterranean diet pertains specifically to skin cancer. The Mediterranean diet has many beneficial effects on dermatological health and chemoprotection against skin cancer. The impact of chemoprotection from a Mediterranean diet allows for development of a nutritional approach to minimize skin cancer incidence and skin cancer metastasis via dietary changes.
Published Version
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