Abstract
Synergy1, a prebiotic composed of Inulin and Oligofructose (1 : 1). Soybean meal is a natural source of isoflavones. The objective was to investigate the effects of feeding Synergy1 and SM on the incidence of azoxymethane- (AOM-) induced aberrant crypt foci (ACF) in Fisher 344 male rats. Rats (54) were randomly assigned to 9 groups (n = 6). Control group (C) was fed AIN-93G and treatment groups Syn1 and SM at 5% and 10% singly and in combinations. Rats were injected with two s/c injections of AOM at 7 and 8 weeks of age at 16 mg/kg body weight and killed at 17 weeks by CO2 asphyxiation. Colonic ACF enumeration and hepatic enzyme activities were measured. Reductions (%) in total ACF among treatment groups fed combinations were higher (67–77) compared to groups fed singly (52–64). Synergistic mechanisms among phytochemicals may be responsible suggesting protective role in colon carcinogenesis with implications in food product development.
Highlights
Cancer is a major public health problem and statistics show that colon cancer is the third leading cause of cancer deaths among men and women in the USA [1]
Values are expressed as means ± SEM; n = 3. abcMeans in the same column with the same letter are not significantly different by Tukey’s studentized range test (P < .05)
Results from our study showed a significantly (P < .05) higher GST activity among treatment groups compared to the control
Summary
Cancer is a major public health problem and statistics show that colon cancer is the third leading cause of cancer deaths among men and women in the USA [1]. Primary prevention is a promising and cost-effective approach in reducing morbidity and mortality related to cancer. Geographical variations in colon cancer prevalence are higher in industrialized nations compared to developing countries which may be explained by the influence of environmental factors such as diet [2]. Diet is one of the modifiable risk factors which has been found to influence colonic microflora and their enzymes in colon carcinogenesis [3,4,5]. Dietary chemoprevention emerged as one of the strategies targeting multistage pathogenesis [6]. Chemoprevention is defined as “use of natural, synthetic, biological or chemical agents to reverse, suppress, or prevent carcinogenic progression [7,8,9]
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