Abstract
Objective: Growing evidence suggests the fallopian tube epithelium harbors the precursor for high-grade serous ovarian cancer, creating opportunities for targeting the fallopian tube for effective chemoprevention. Animal and human evidence has shown that progestins confer potent cancer preventive effects in the gynecologic tract by activating molecular pathways that clear genetically damaged cells. in addition, it has been shown in vitro that the potency of progestins can be enhanced with vitamin D.
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