Abstract
An Andrographis paniculata leaf and stem extract was studied in Hela cells lines by In Vitro methods and anti promoting effect by skin tumour model. The dose dependent cytotoxicity was observed in HeLa cell lines by stem and leaves extracts of Andrographis paniculata extract. The prevention of bone marrow micronucleus formation by Andrographis paniculata leaves and stem extract was also observed. The reductions in tumour numbers were observed. The glutathione level was increased in the liver of animals which received the treatment of Andrographis extract along with DMBA + Croton Oil. The revealing information about the anticancer, antiproliferative and antimutagenic effect of an Andrographis paniculata extract was observed.
Highlights
Andrographis paniculata is used in Asia from centuries in traditional medicine to treat gastrointestinal (GI) tract and respiratory infectious diseases
Cumulative number of papillomas was reduced in the Andrographis paniculata leaves and stem extract treated along with Dimethylbenz (a) anthracene (DMBA) + Croton Oil groups
The current study demonstrates anticarcinogenic, antoproliferative and antimutagenic potential of Andrographis paniculata stem and leaves (AP) extract in skin papillomas, Hela cells lines and in bone marrow micronucleus assay
Summary
Andrographis paniculata is used in Asia from centuries in traditional medicine to treat gastrointestinal (GI) tract and respiratory infectious diseases. It has been reported that Andrographis has a broad range of pharmacological effects [1]. It has been suggested it’s safe in controlled clinical trials report for treating upper respiratory tract infections. It showed significant cardio protection by inducing antioxidant activity in myocardium [2]. Cytotoxic activity against cancer cell lines has been reported by Compounds of Andrographis paniculata [3]. An andrographolide was reported to induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax, immuno histochemical parameters such as caspase-3 and decrease expression of bcl-2 [8]. The extract produced significant muscarinic activity, which accounts for its antivenom effects . [10] Many of the conditions commonly treated with Andrographis paniculata in traditional medical systems are important, which requires further investigations for benefit in cancer treatment
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