Abstract
The kinetic resolution of ferrocenyl aldol 2 was achieved by a lipase-catalyzed esterification in organic solvent. Lipase from Candida antarctica was also found effective in promoting the enantioselective alcoholysis of acetate (±)- 3 with n-BuOH. Both enantiomers of 2 were obtained in enantiopure form and subjected to chemical reduction to afford the corresponding syn- and anti-diols. These diols serve as starting materials for the preparation of new ferrocenyl amino alcohols bearing two stereocenters in the side chain.
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