Chemo protective activity of Phyllanthus niruri and Opuntia ficus indica plant extract

Abstract

Cancer is one of the leading causes of death. Several chemotherapeutical agents have been used to treat cancer, and yet a convincing cure is elusive in most cases. Therefore, there is continued need for development of new anticancer agents. Angiogenesis is one of the vital events for organ development and differentiation during embryogenesis as well as wound healing and reproductive functions in adults. Angiogenesis also contributes significantly to tumors growth and metastasis. Currently, search for effective anti-angiogenesis agents and therapy is an emerging field. Cytotoxic agents with anti-angiogenic activity are designated to control tumors endothelial cell growth and tumour cell survival. Therefore, combinatorial therapy in which anti-angiogenic agents with chemotherapeutic activity administrated in a scheduled manner could result in a much more favorable therapeutic effect. India is one of the richest bio diversity centers with respect to medicinal plants. Many plants have been utilized in the traditional system of medicine for cancer treatment. The plants have been utilized as medicines from thousands of years ago. The isolation of active components from plants began with the morphine isolation from opium plant. In the present study, Phyllanthus niruri and Opuntia ficus-indica were screened for the phytochemical and anticancer evaluation.
 Keywords: Anti-Cancer, Anti-Oxidant, Phyllanthus niruri, Opuntia ficus-indica, in vivo study.