Abstract
The chemistry of 1,2,3,7,8,12b-hexahydro-, 1,7,8,12b-tetrahydro-, and 7,8-dihydrobenzo[1,2]cyclohepta[3,4,5-d,e]isoquinolines has been investigated, leading to the synthesis of a wide variety of derivatives bearing substituents in the 2- and 3-position. Also, the reactions of 1,7,8,12b-tetrahydrobenzo[1,2]cyclohepta[3,4,5-d,e]isoquinoline with 1-buten-3-one, methyl mercaptoacetate, and 3-mercaptopropionic acid have yielded representatives of three novel pentacyclic systems; benzo[4,5]cyclohepta[1,2,3-g,h]-benzo[a]quinolizine, benzo[1,2]cyclohepta[3,4,5-d,e]thiazolo[2,3-a]isoquinoline, and benzo[1,2]cyclohepta[3,4,5-d,e]-1,3-thiazino[2,3-a]isoquinoline. The central nervous system and cardiovascular pharmacology of the compounds have been investigated and the results are presented.
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