Abstract

The functional characterisation of endogenous neural substances demands the concerted efforts of investigators in numerous disciplines, a point that is adequately illustrated in the proceedings of this symposium. Over the past 20 years, electrophysiological techniques have provided a most valuable insight into the function of diverse excitable tissues, especially the nervous system. Because of its excellent time resolution, relatively simple technology and often unequivocal interpretation, electrophysiology has continued to be a most useful method for real-time monitoring of neuronal activity especially at the cell and/or membrane level. Electrophysiological techniques have been used to elucidate basic mechanisms of synaptic transmission, and continue to be of major importance in the sometimes frustrating analysis of complex neural organisation and behaviour. A large portion of our knowledge of central nervous system (CNS) pharmacology is derived from the analysis of drug effects on the electrical activity of the nervous system.

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