Abstract
A stereoselective total synthesis of (+)-cassaine (1) via an anionic polycyclization methodology is described. Commercially available (+)-carvone (5), the only chiral source, was used to fix the entire stereochemistry of the natural product. Anionic polycyclization of a new substituted 2-(methoxycarbonyl)cyclohex-2-en-1-one (4) with known 1-phenylysulfinyl-3-penten-2-one (3) provided the versatile tricycle (2) with requisite stereochemistry. A sequence of functional group manipulations of tricycle (2) furnished the natural product 1.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
