ChemInform Abstract: Thieno[2,3‐d]pyrimidines and ‐[1,3]oxazines as Glutamate Antagonists and Investigations on the Inhibitory Potency Toward Human Leukocyte Elastase.

Abstract

AbstractFused thiophene derivatives such as thienopyrimidines, thienooxazines, and thienothiazines with the common 5‐methyl‐6‐phenyl substitution pattern are designed and synthesized as cyclic analogues of a particularly active antagonist at the GluR6 kainate receptor.