Abstract
Abstract In this study, the potential of N -alkoxymethyl groups as protectants for the peptide backbone has been investigated. These groups were found to be compatible with the standard conditions of Fmoc/ t Bu SPPS, and can be cleaved off from the peptide backbone by acids. Thus, backbone N -alkoxymethyl groups may be useful to prevent undesired side-reactions and/or interchain aggregation during peptide elongation on the solid-phase. However, the main issue for their application as protecting groups is the difficulty to incorporate them into the peptide backbone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have