ChemInform Abstract: THE CHEMISTRY OF ISOXAZOLIDINES

Abstract

Publisher Summary This chapter reviews the chemistry of isoxazolidines in the literature up to 1974. The parent isoxazolidine can be named as 1,2-oxazolidine according to the extension of the Hantzsch-Widman system. It is noted that the hydro-isoxazole or isoxazoline nomenclature is used specifically in connection with the condensed ring. The most important method of isoxazolidine ring formation involves simultaneous formation of the 1:5 and 3:4 bonds. A limited number of reactions involve formation of the 1:5 and 2:3 bonds. The chapter describes synthetic methods of preparations, spectroscopic, physical, and chemical properties along with the uses of isoxazolidines. Some isoxazolidines and their quaternary salts are physiologically active, such as 2-isoxazolidines, which are effective as the herbicides for a variety of weeds, such as wild oats charlock, red shanks, stinging nettle, and chickweed. N-aroylisoxazolidines are reported to exhibit central nervous depressant activity without muscle relaxant effect.