Abstract

Abstract Syntheses of four N -Fmoc δ-amino acids with an ether linkage in the main chain and four different nucleobases on the side chain, Fmoc-NH-C ∗ H(CH 2 -CH 2 -B)-CH 2 -O-CH 2 -COOH (B =thymine, uracil, N 4 -benzoylcytosine, and N 2 -isobutyrylguanine) are described. The δ-amino acids were prepared through 8–12 step synthesis starting from l -homoserine and could be linked together to form novel peptide nucleic acids (oxy-PNAs = OPNAs).

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