ChemInform Abstract: Synthesis of 3′-Ethynylthymidine, 3′-Vinylthymidine, and 3′- Bromovinylthymidine as Potential Antiviral Agents.

Abstract

Abstract The synthesis of three novel 3′-unsaturated carbon analogues of AZT and FLT is described. The key step in the synthesis is a Cu(I)- catalyzed addition of vinylmagnesium bromide to a 2,3-unsaturated lactone, followed by, in the case of compounds 2 and 3 , elimination reactions of a dibromo-compound.