ChemInform Abstract: Silver(I)‐Mediated Regioselective Oxidative Cross‐Coupling of Phenol and Aniline Derivatives Resulting in 2′‐Aminobiphenyl‐2‐ols.

Abstract

Abstract A broad and efficient regioselective aerobic oxidative cross-coupling of phenols and aniline derivatives in the presence of AgNO3 and H2O2 resulting in 2′-aminobiphenyl-2-ols has been developed. This reaction is selective toward the creation of a new C C bond at the ortho position to both amine and hydroxyl functional groups in the respective starting materials. Although oxidative cross-coupling of phenols and anilines resulting in 2′-aminobiphenyl-2-ol derivatives have been reported, these reactions have been mainly limited to 2-naphthol and 1-naphthol. This is one of the rare reports in which this type of cross-coupling reaction is expanded to simple phenol derivatives.