ChemInform Abstract: Practical Synthesis of BILA 2157 BS, a Potent and Orally Active Renin Inhibitor: Use of an Enzyme-Catalyzed Hydrolysis for the Preparation of Homochiral Succinic Acid Derivatives.

Pierre L Beaulieu,Jean‐Simon Duceppe,Dominik Wernic,Murray Bailey,Christian Beaulieu,James Gillard,Pierre Lavallee

doi:10.1002/chin.200003193

ChemInform Abstract: Practical Synthesis of BILA 2157 BS, a Potent and Orally Active Renin Inhibitor: Use of an Enzyme-Catalyzed Hydrolysis for the Preparation of Homochiral Succinic Acid Derivatives.

Pierre L Beaulieu, Jean‐Simon Duceppe + Show 5 more

https://doi.org/10.1002/chin.200003193

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Journal: ChemInform

Publication Date: Jun 11, 2010

Affiliation: Boehringer Ingelheim (Germany)

#Active Inhibitor #Convergent Synthesis + Show 8 more

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Abstract

We have developed a highly convergent and stereoselective synthesis of BILA 2157 BS, a potent and orally active renin inhibitor. The synthesis proceeds in 15 distinct chemical steps (with several i...

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