Abstract
Abstract Three new polyketides including one new diphenyl ether, penicillither ( 1 ), one new anthraquinone, penicilliquinone ( 2 ), and one new xanthone, penicillixanthone ( 3 ), together with twelve known compounds were isolated from the soil fungus Penicillium sp. PSU-RSPG99. Their structures were identified by spectroscopic evidence. In addition, the position of a chlorine atom in 1 was confirmed by the plausible biosynthetic pathway from the isolated chlorobenzophenone. Known GKK1032B displayed mild antimycobacterial and moderate cytotoxic (against human oral carcinoma, KB, human breast cancer, MCF-7, and noncancerous Vero cell lines) activities.
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