ChemInform Abstract: One‐Pot Synthesis of Pyrrolo[3,4‐a]indolizine‐1,3‐diones Through [3 + 2] Cycloaddition‐Oxidation Reaction Catalyzed by CuII Salt and O2 as the Oxidant.

Abstract

An efficient one-pot synthesis of pyrrolo[3,4-a]indolizine-1,3-diones has been developed from maleimides, pyridines, and acyl bromides through a [3+2] cyclization–oxidation reaction catalyzed by CuII salt under O2 atmosphere. The advantage of this method is the use of molecular oxygen as the oxidant, in the presence of a catalytic amount of hydrated copper(II) chloride, to accomplish the reaction with broad substrate scope and excellent yields.