Abstract
An efficient one-pot synthesis of pyrrolo[3,4-a]indolizine-1,3-diones has been developed from maleimides, pyridines, and acyl bromides through a [3+2] cyclization–oxidation reaction catalyzed by CuII salt under O2 atmosphere. The advantage of this method is the use of molecular oxygen as the oxidant, in the presence of a catalytic amount of hydrated copper(II) chloride, to accomplish the reaction with broad substrate scope and excellent yields.
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