Abstract
An enantioselective Michael addition of ethyl 4,4,4-trifluoro-3-oxobutanoate to α,β-unsaturated ketone esters using a chiral alkyl-substituted thiourea catalyst is reported. Excellent levels of stereo-induction (up to 98% ee) under mild reaction conditions were obtained to afford the corresponding α-trifluoromethyldihydropyrans.
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