Abstract
AbstractAn enantioselective Michael addition of ethyl 4,4,4‐trifluoro‐3‐oxobutanoate to α,β‐unsaturated ketone esters using a chiral alkyl‐substituted thiourea catalyst is reported. Excellent levels of stereo‐induction (up to 98% ee) under mild reaction conditions were obtained to afford the corresponding α‐trifluoromethyldihydropyrans.
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