Abstract
Abstract 5-Aryl-substituted annulated pyridines can be accessed directly from the corresponding acetylene substituted pyrimidines through an intramolecular inverse-electron-demand hetero -/ retro -Diels–Alder ( ih DA/ r DA) reaction cascade carried out in continuous flow. Exploiting this new process, a series of cycloalka[ c ]pyridines that represent useful building blocks for medicinal chemistry were prepared in good to excellent yields with short processing times (
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