ChemInform Abstract: Direct Construction of 5‐Methyl‐2‐phenylisoxazol‐3(2H)‐ones via Hypervalent Iodine Mediated Sequential Tandem Oxidative Cyclization of 3‐Oxo‐N‐phenylbutanamides Catalyzed by Zinc Oxide (ZnO).

Weibing Liu,Cui Chen,Zhibo Zhu,Qing Zhang,Peng Zhou

doi:10.1002/chin.201323122

ChemInform Abstract: Direct Construction of 5‐Methyl‐2‐phenylisoxazol‐3(2H)‐ones via Hypervalent Iodine Mediated Sequential Tandem Oxidative Cyclization of 3‐Oxo‐N‐phenylbutanamides Catalyzed by Zinc Oxide (ZnO).

Weibing Liu, Cui Chen + Show 3 more

https://doi.org/10.1002/chin.201323122

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Journal: ChemInform

Publication Date: May 16, 2013

Affiliation: Guangdong University of Petrochemical Technology

#Zinc Oxide #Sequential Cyclization + Show 8 more

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Abstract

A sequential oxidative tandem cyclization reaction mediated by a combination of (diacetoxyiodo)benzene (DIB) with zinc oxide (ZnO) is presented for the synthesis of 5-methyl-2-phenylisoxazol-3(2H)-ones from β-ketobutylanilides. A variety of β-ketobutylanilide compounds were used in this approach, and a wide range of functionalized 5-methylisoxazol-3(2H)-ones were obtained in good to excellent yields.

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