Abstract
The aldol reaction of the substituted cyclopentane carbaldehydes 1 with heptan-2-one was demonstrated to offer an effective alternative to the carbonyl olefinations generally used for the build-up of the (E)-3-oxooct-1-enyl side chain of 11-deoxyprostaglandins. In this case dimethyl 2-oxoheptylphosphonate can be substituted advantageously by the cheaper heptan-2-one as side chain precursor.
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