Abstract
(S)-N-(tert-Butylsulfinyl)-3,3,3-trifluoroacetaldimine underwent reactions with enolates of glycine esters with quite remarkable stereochemical results, that is, with virtually complete (>99 % de) diastereoselectivity and excellent (>98 %) yields. Furthermore, the reactions are conducted under operationally convenient conditions (Cs2CO3-catalyzed, ambient temperature) to provide the most advanced, general, and scalable access to biologically important β-trifluoromethylated α,β-diamino acids.
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