ChemInform Abstract: Catalytic Asymmetric Activation of a C(sp3)—H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α‐Alkyl α‐Amino Acids and C1‐Alkylated Tetrahydroisoquinoline Derivatives.

Abstract

AbstractThe DDQ‐mediated cross‐dehydrogenative coupling of a variety of oxocyclopentanecarboxylates or analogues with glycine esters is efficiently catalyzed by Cu(II)/chiral bisoxazoline.