ChemInform Abstract: Asymmetric Diels—Alder Reaction of β,β‐Disubstituted Enals and Chromone‐Fused Dienes: Construction of Collections with High Molecular Complexity and Skeletal Diversity.

Abstract

An asymmetric inverse-electron-demand Diels–Alder reaction of chromone-fused dienes and β,β-disubstituted α,β-unsaturated aldehydes has been developed via dienamine catalysis. Different domino or sequential transformations could be carried out for electron-deficient dienes with variously substituted patterns, allowing for the efficient construction of caged or fused tetrahydroxanthones with high molecular complexity and skeletal diversity in excellent diastereo- and enantioselectivities.