Abstract
An efficient synthesis of pyrido[2,3-d]pyrimidine derivatives via one-pot multicomponent reactions of 6-amino-2-(alkylthio)pyrimidin-4(3H)-one, 3-cyanoacetylindole and arylaldehydes using [Fe3O4@ZrO2] as magnetically recyclable nanocatalyst is reported. This protocol furnished the desired products in good to excellent yields (70–93 %) and lower reaction times. The catalyst could be easily and efficiently separated from the final product solution by an external magnet and be reused in 5 consecutive runs without any significant activity decrease.
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