Abstract

An efficient formal synthesis of the potent protein kinase C inhibitor (−)-balanol that relies on a modified asymmetric aminohydroxylation of the α,β-unsaturated aryl ester (1) is reported. The aryl ester functionality and the dihydroquinyl alkaloid ligand system (DHQ)2−AQN are used to control the regio- and enantioselectivity of the process.

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