ChemInform Abstract: A Tactical Approach for the Synthesis of Novel β‐Lactam‐Substituted, Polycyclic‐Fused Isoxazolidine Derivatives via an Intramolecular [3 + 2] Cycloaddition Reaction.

Abstract

Abstract The synthesis of functionalized β-lactam-substituted, tricyclic chromenoisoxazolidine and tetracyclic naphthopyranoisoxazolidine derivatives by intramolecular nitrone cycloaddition reaction is described. The O-allyl hydroxyaldehyde derivatives, obtained from Baylis–Hillman adducts (BHA) derived from β-lactam aldehyde underwent intramolecular cycloaddition reaction to give β-lactam-substituted, polycyclic isoxazolidine derivatives in good yield. All the products were confirmed by spectral analysis. The products with a β-lactam substituent may find good applications in biological chemistry.