Abstract
A convergent and stereoselective total synthesis of decarestrictine I, a polyketide natural product, is described. Both acid and alcohol fragments were prepared from the readily available L-malic acid via StillGennari olefination and Sharpless asymmetric epoxidation. The Steglich esterification and ring-closing metathesis (RCM) are employed to combine both acid and alcohol fragments.
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