Abstract
Abstract A highly convergent method for the synthesis of trans -fused polytetrahydropyrans was developed, which involves: (i) coupling of cyclic triflate with an acetylene unit; (ii) oxidation of acetylene to 1,2-diketone; (iii) formation of a trans -fused cyclic dihemiacetal; (iv) O -methylation of the dihemiacetal; and (v) stereoselective reduction of the diacetal to trans -fused oxane rings.
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