ChemInform Abstract: A Novel and Efficient Methodology for Thio‐Michael Addition in the Synthesis of cis‐β‐Thio‐α‐aminoacid Derivatives Using Zn[(L)‐Pro]2 as Heterogeneous Catalyst.

Abstract

A simple, efficient and green chemical ultrasound assisted thio-Michael addition reaction between thiols and (Z)-azlactones aiming to produce non-natural amino acid derivatives by using chiral Zn[(L)-Pro]2 as a heterogeneous catalyst is herein described. The product was obtained in good to excellent yields presenting high diastereoselectivity.