Abstract
Abstract A facile and consecutive one-pot, multi-component reaction for synthesis of trifluoromethylated spirochromeno[2,3- c ]-6 H -pyrazol-2′,5-dione derivatives by the reaction of isatin, cyclohexane-1,3-dione and 1-aryl-3-(trifluoromethyl)-1 H -pyrazol-5(4 H )-one in the presence of p - toluenesulfonic acid ( p -TSA) with good yields was reported. Compared with the stepwise reactions, the p -TSA played dual roles as both catalyst and dehydrating agent in the conversion. The structures of new compounds were determined by spectroscopic methods and X-ray diffraction analysis. In addition, a possible mechanism for the formation of compound 5 was presented.
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