ChemInform Abstract: (2S,5R)‐2‐Methylaminomethyl‐1‐methyl‐5‐phenylpyrrolidine, a Chiral Diamine Ligand for Copper(II)‐Catalyzed Henry Reactions with Superb Enantiocontrol.

Abstract

AbstractExcellent yields and superb levels of enantiocontrol are achieved in Cu(II)‐catalyzed Henry reactions of aromatic, heteroaromatic, vinylic, and aliphatic aldehydes in the presence of a chiral pyrrolidine ligand derived from L‐pyroglutamate.