Enantioselective Cu(II)-catalyzed Henry reactions with chiral cyclohexane-based amidophosphine ligands

Abstract

Copper-catalyzed asymmetric Henry reactions are described. Using a new chiral amidophosphine ligand, the Henry reaction of nitromethane and various aldehydes proceeded smoothly to provide chiral β-nitroalcohols in reasonable yields (up to 98%) with high enantioselectivity (up to 97% ee).