Abstract
Oral administration of a glucose transport inhibitor, 2,6-di- tert-butylamino-3-acetyl-4-methylpyridine (SaH 51-055), resulted in the formation of lipid droplets in the lamina propria of the villi of the duodenum in young male rats. A time sequence, electron microscopic study revealed an accumulation of a coalesced form of lipid between epithelial cells of the terminal villi and within macrophages in the lamina propria as early as 6 hr after administration. Rupture of macrophages occurred after further lipid accumulation and intercellular lipid droplets were found in the lamina propria of the tips of the duodenal villi. It is though that this phenomenon may be due to abnormalties in the triglyceride resynthesis process or protein synthesis in the duodenal epithelial cells.
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