Abstract
Wound dressings are highly desired for the treatment of chronic wound infections. This study aimed to prepare membranes composed of chemically crosslinkedPVA and Gelatin polymers. Curcumin was added to improve the membrane's biological properties. FTIR spectroscopy was used to investigate their chemical structures, while SEM and TGA analysis were applied to studies the morphology of the membrane and the thermal properties of the crosslinked membranes. In addition, the contact angle measurement was also performed to get more information about the physicochemical properties. In addition, the biodegradability studies were performed and the findings highlighted that the prepared biodegradable PVA/ Gelatin/ Curcumin membranes could be efficiently used as dressers for enhancing wound healing.
Highlights
Polyvinyl alcohol (PVA) is a linear synthetic polymer produced via partial or full hydrolysis of polyvinyl acetate to convert the acetate groups to hydroxyl groups
PVA stabilization forming hydrogel membranes Fig. (1) represented photos of the formed chemically crosslinked films that formed after casting the PVA in Petri dishes with glutaraldehyde
Fig. (3) represented gel fraction of crosslinked PVA/ Gelatin/ Curcumin membranes and it was appeared that the highest PVA content had the highest crosslinking degree and highest stability and incorporation of gelatin in content of membranes decreasing gel fraction percent and the highest gelatin content had the least crosslinking degree which confirm PVA crosslinking after glutaraldehyde addition
Summary
Polyvinyl alcohol (PVA) is a linear synthetic polymer produced via partial or full hydrolysis of polyvinyl acetate to convert the acetate groups to hydroxyl groups. The amount of hydroxylation determines the physical characteristics, chemical properties, and mechanical properties of the PVA [1]. The resulting PVA polymer is highly soluble in water but insoluble in organic solvents. The higher the degree of hydroxylation and polymerization of the PVA, the lower the solubility in water and the more difficult it is to crystallize [2]. Due to its water solubility, PVA needs to be crosslinked to form hydrogels for use in several applications. The degree of crosslinking dictates the amount of fluid uptake, and the physical, chemical, and diffusional properties of the polymer, and its biological properties
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