Chemically cross-linked albumin microspheres for the controlled release of incorporated rose bengal after intramuscular injection into rabbits

Abstract

The clearance of rose bengal from an intramuscular injection site has been delayed, and the whole body retention of the compound extended, by its incorporation into albumin microspheres cross-linked with glutaraldehyde. The magnitude of this modification in the release and clearance of the rose bengal was directly related to the density of the cross-linked matrix of the microspheres. Results suggest that the higher the density of cross-linking of the albumin microspheres, the slower the rate of their biodegradation, and thus the slower the rate of release of rose bengal.