Chemical Synthesis, Characterization and DNA Binding Studies of 2, 4- Dihydroxy Acetophenone Pramipexole Schiff Base Metal Complexes

Abstract

Schiff and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities, including antifungal, antibacterial, anti-malarial, ant proliferative, anti-inflammatory, antiviral, and antipyretic properties. Many Schiff base complexes show excellent activity in various reactions in the presence of moisture. Over the past few years, many reports have been on their applications in homogeneous and heterogeneous catalysis. The influence of certain metals on the biological activity of these compounds and their intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behavior. The development of new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. The present paper deals with synthesizing and characterizing metal complexes of new Schiff bases derived from Pramipexole (4, 5, 6, 7-Tetrahydro-N6-propyl-2, 6-benzothiazole diamine) and 2,4- dihydroxy acetophenone (2,4 DHAP) by using modified Sand Mayer's method. Synthesized complexes were characterized by several techniques using IR, 1HNMR, UV-visible spectrometry, TG-DTA, and Conduct Metric Titrations. Infrared spectral data indicate the coordination between ligand and central metal ion through deprotonated phenolic oxygen and azomethine nitrogen. In addition, the authors have screened the compounds for DNA binding studies. It was found that these complexes bind DNA with high affinities.