Abstract
Tretinoin is commonly used in dermatological preparations, for example in the treatment of acne vulgaris. Tretinoin or all trans retinoic acid is easily oxidizable, thermally unstable and it isomerizes fast when exposed to radiation. In this investigation, the chemical stability of tretinoin was studied in different dermatological preparations. For this purpose, accelerated stability analysis was carried out and also the influence of daylight was investigated. To analyze the dermatological preparations, a HPLC method on a reverse-phase column seemed to be the most suitable one and also the sample preparation for this method was relatively simple. The decomposition of tretinoin in preparations which were exposed to radiation was very fast. A 10% decomposition was noted between less than 1 h and 181 h, depending on the formulation of the preparation. The tretinoin stability was also influenced by temperature, depending on the ingredients of the dermatological preparations. The adjuvant Brij 35 S, used as solubilizing agent, had a very bad influence on the chemical stability of tretinoin.
Published Version
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