Abstract
A silver(I) complex with succinic acid in the form of succinate is presented. Chemical characterization confirms the molecular composition Ag2C4H4O4 for the complex. Infrared spectra suggest a bidentate coordination of both carboxylate groups of succinates to the two Ag(I) ions. Density functional theory (DFT) studies were used in the structures of succinic acid and Ag(I) succinate complex with coordination formula [Ag2(C4H4O4)] in order to optimize them to their minimum energy. The studies confirmed that each carboxylate group of the succinate anion is coordinated to one silver atom by the two oxygen in a bidentate mode and the bond lengths O···Ag theoretically determined range from 2.325 to 2.338 Å. The complex [Ag2(C4H4O4)] showed in vitro antibacterial activity against the bacterial strains of Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa complex. Anti-Mycobacterium tuberculosis analyses were also performed and the [Ag2(C4H4O4)] complex was shown to be active over M. tuberculosis H37Rv strain with MIC90 of 23.94 μg mL-1 while succinic acid itself showed a value higher than 25.00 μg mL-1.
Highlights
According to recent reviews[1,2], the bacterial antibiotic resistance is increasing at an alarming rate
Density functional theory (DFT) studies were used in the structures of succinic acid and Ag(I) succinate complex with coordination formula [Ag2(C4H4O4)] in order to optimize them to their minimum energy
The results indicate that the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) orbitals of succinic acid, as well as the HOMO of [Ag2(C4H4O4)], are located over all molecular structures
Summary
According to recent reviews[1,2], the bacterial antibiotic resistance is increasing at an alarming rate. One of the most common bacterial strains is Escherichia coli, which is usually found in intestines of warm-blooded organisms. Most strains of E. coli are harmless, but some can cause severe food poisoning. It is transmitted to humans mostly by the ingestion of contaminated foods, such as raw meat, milk and vegetables. Escherichia coli can cause neurological complications (seizures, stroke and coma) in about 25% of patients with hemolytic uremic syndrome and chronic kidney sequelae in about 50% of survivors. The E. coli resistance to the standard antibiotic treatment with fluoroquinolones is widespread. In some countries, this treatment has shown to be ineffective in more than 50% of patients[3]
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