Abstract
Carbonized pollen grains of Typha (CPT) were widely used in clinical for antithrombosis, wound and bleeding in China. In order to ensure the role of drugs, it is very important to control the quality of drugs. However, there is a lack of monitoring methods in the process of charcoal preparation. To characterize the process of CPT, we used thermal analysis, scanning electron microscope (SEM), color measurement, Fourier transform infrared spectrometry (FTIR) and HPLC. In this study, 7 min was the optimal processing time and the heating process condition should be controlled under 272.35 ± 7.23 °C. This comprehensive strategy to depict the whole carbonizing process would provide new ideas for researches on quality control of Traditional Chinese Medicine (TCM) and processing theory of charcoal medicine.
Highlights
Charcoal medicine, named ‘Tan Yao’ in China, is a kind of special processing product in Chinese medicine and used for treatment of hemoptysis, hematemesis, and hemorrhage in clinic during ancient times [1]
Pollen Grains Observed by scanning electron microscope (SEM) during Heating Process
The date was consistent with the temperature of maximum thermal weight loss. These results suggested that the temperature should be controlled under 272.35 ± 7.23 ◦ C during the heating process
Summary
Charcoal medicine, named ‘Tan Yao’ in China, is a kind of special processing product in Chinese medicine and used for treatment of hemoptysis, hematemesis, and hemorrhage in clinic during ancient times [1]. The principal way to prepare charcoal medicine is carbonizing the drugs by high-temperature heating [2]. Some of the components will be lost during the process of carbonizing but the efficacy of hemostatic will be enhanced and the toxic effect of the crude drug will be reduced according to the Traditional Chinese. Pollen Typha (PT) is a well-known TCM medicine widely used in clinical for antithrombosis [5], wound, and bleeding [6]. Both the raw pollen grains and the PT charcoal are listed in the Pharmacopoeia of the People’s Republic of China (2015 edition). One is putting the pollen grains into a heating container to stir fry them to deep yellow, named stir frying PT (SPT) and the other is baking them to brown, named carbonized PT (CPT) [7]
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