Abstract
Several Baccharis species are popularly known in traditional medicine as "carquejas", "vassouras", "ervas-santas" and "mio-mios", and areused as anti-inflammatories, digestives, and diuretics. Therefore, this study aimed to investigate the chemical compositions, performing graphical analysis of multivariate data and test cytotoxic activities of essential oils (EOs) of six Baccharis species belonging to subgenus Coridifoliae, namely B. albilanosa, B. coridifolia, B. erigeroides, B. napaea, B. ochracea and B. pluricapitulata. GC-MS analyses of the EOs showed that the oxygenated sesquiterpenes spathulenol (7.32-38.22%) and caryophyllene oxide (10.83-16.75%) were the major components for all the species. The EOs of almost all species were cytotoxic against cancer (BT-549, KB, SK-MEL and SK-OV-3) and normal kidney (VERO and LLC-PK1) cell lines, whereas B. erigeroides EO showed cytotoxicity only against LLC-PK1. This paper augments the current knowledge about the chemical-biological properties of Baccharis subgenus Coridifoliae and discusses the therapeutic potentials of these economically unexploited plants.
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