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Abstract
>The human corona virus disease of 2019 is a viral disease that can produce oxidative stress due to reduced antioxidant activity. Black cumin is a plant that can be taken as a supplement to boost antioxidant levels in the body, although the process is still unknown. As a result, the in silico method will be used to screen the potential of Nigella sativa peptide as an antioxidant in this study. Protein tracking was done using the UniProt database, with KEAP1 as the target protein (GDP: 5CGJ). Molecular docking was performed using Patchdock Server and antioxidant activity was determined using https://services.healthtech.dtu.dk/service.php?AnOxPePred-1.0. The researchers concluded that peptides found in N. sativa’s NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic protein, had antioxidant potential through suppressing KEAP1 activity with the lowest ACE in Tyr-Tyr-Glu and Cys-Tyr-Tyr.
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