Chemical Constituents of Cordia dichotoma G. Forst.

Consolacion Y Ragasa,Sylvia Urban,Virgilio Ebajo Jr,Robert BrkljaäA,Mariquit M De Los Reyes,Emelina H Mandia,Maria Carmen S Tan

doi:10.7324/japs.2015.58.s3

Abstract

Chemical investigation of the dichloromethane extracts of Cordia dichotoma G. Forst led to the isolation of β- sitosteryl-3β-glucopyranoside-6'-O-palmitate (1), nervonyl 4-hydroxy-trans-cinnamate ester (2), β-sitosterol (3), and chlorophyll a (4) from the leaves; and 4 and 1,2-dilinoleoyl-3-linolenoylglycerol (5) from the twigs. The structures of 1-5 were identified by comparison of their NMR data with those reported in the literature. The fatty acids in 1, 2 and 5 were deduced from ESI-MS data.

Highlights

We report the isolation of β-sitosteryl-3βglucopyranoside-6'-O-palmitate (1), nervonyl 4-hydroxy-transcinnamate ester (2), β-sitosterol (3), and chlorophyll a (4) from the leaves; and 3 and 1,2-dilinoleoyl-3-linolenoylglycerol (5) from the twigs of C. dichotoma (Fig. 1)
This study reports on the isolation of compounds (1-5) from the dichloromethane extracts of the leaves and stems of C. dichotoma
The medicinal properties of C. dichotoma maybe partly attributed to 1-4 which were reported to exhibit diverse biological activities

Summary

Introduction

This medium sized tree grows widespread in the Philippines where it is locally known as anonang. It yields edible fruits from which a very sticky white substance could be extracted for gluing purposes. The leaves, fruit, bark and seed have been reported to exhibit antidiabetic, antiulcer, antiinflammatory, immune-modulator and analgesic activities (Jamkhande et al, 2013). The leaves, seed, fruit, bark, and roots are well-known to have different medicinal uses: antidiabetic, anthelmintic, antilarvicidal, hepatoprotective, immunomodulator, antidysentery, antidyspepsia, anti-inflammatory, antiulcer, diuretic and laxative (Patel et al, 2011). The crude ethanol extract from the leaves showed antilarvicidal potency against the brine shrimp Artemia salina (Sharker et al, 2013).

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Conclusion