Abstract
In this work, the volatile components of Erigeron sublyratus essential oils and their anti-inflammatory and cytotoxic activities were investigated for the first time. Gas chromatography-mass spectrometry (GC-MS) analysis identified 28 components in the root and aerial part essential oils. The main components included cis-lachnophyllum ester (53.4-64.2 %), germacrene D (5.6-8.6 %), trans-β-ocimene (2.6-7.5 %), β-caryophyllene (4.7-6.8 %), β-myrcene (2.0-6.3 %), and (E)-β-farnesene (4.8-5.0 %). The aerial part essential oil inhibited nitric oxide (NO) production on LPS-induced RAW 264.7 cells, with an IC50 value of 1.41±0.10 μg/mL. In addition, both root and aerial part essential oils exhibited cytotoxic activity against MCF-7, SK-LU-1, and HepG2. Molecular docking simulation results revealed that (E)-β-farnesene strongly binds to the VEGFR-2 enzyme, while δ-cadinene has a high affinity to the COX-2 enzyme via hydrophobic interactions. These findings proposed that E. sublyratus essential oils can be exploited for their anti-inflammatory and anti-cytotoxicity potential.
Published Version
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