Abstract
Phytolacca, which belongs to the family of Phytolaccaceae, are known for their use in popular medicine. Bioactivity of five extracts from Phytolacca dioica seeds were evaluated in four bioassays. A selected group of compounds from the extract that displayed the best bioactivity was analysed. The ethyl acetate extract (EAE) possessed the highest content of phenolics, the highest inhibitory activity on the tyrosinase and xanthine oxidase enzymes and showed a high antioxidant activity. HPLC-DAD-MS was employed to identify the phenolics profile of the most active one (EAE). HSCCC analysis of the EAE led to the isolation of phytolaccoside B and a mixture of 4 isomers, isoamericanol B1, B2, C1 and C2. These isoamericanol isomers presented activity against tyrosinase and xanthine oxidase. Our results revealed for the first time an interesting biological activity of the extract and isolated compounds from P. dioica seeds, which could be considered as a source of bioactive molecules.
Highlights
In the last years, the evaluation of medicinal plants and the isolation of their bioactive compounds have substantially increased due to their potential use as drugs in modern medicine.Different pharmacologically active compounds from medicinal plants, which can improve health, may act individually, additively or in synergy[1,2].The plant kingdom offers a considerable amount of plants with potential as drug candidates
To give some insight into the chemical composition of P. dioica seeds, quali-quantitative information on the individual fatty acids in HE extracts was obtained by GC and HPLC-diode array detector (DAD) analyses
The results of this study showed that the ethyl acetate extract of P. dioica seeds possessed a good XO and tyrosinase inhibitory activity
Summary
The evaluation of medicinal plants and the isolation of their bioactive compounds have substantially increased due to their potential use as drugs in modern medicine.Different pharmacologically active compounds from medicinal plants, which can improve health, may act individually, additively or in synergy[1,2].The plant kingdom offers a considerable amount of plants with potential as drug candidates. The evaluation of medicinal plants and the isolation of their bioactive compounds have substantially increased due to their potential use as drugs in modern medicine. Different pharmacologically active compounds from medicinal plants, which can improve health, may act individually, additively or in synergy[1,2]. The plant kingdom offers a considerable amount of plants with potential as drug candidates. Species of the genus Phytolacca, family Phytolaccaceae, are known for their use in popular medicine. Several ailments have been treated using these plants and different pharmacological actions have been reported, including antimicrobial, anti-inflammatory and anticancer[3,4,5,6]. Ethnopharmacological information revealed that Phytolacca dioica is used to heal skin wounds[7]
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