Abstract
The natural product of tamanu oil is valuable in medicine and cosmetic. In this study, the tamanu oil was extracted by supercritical CO2 (sCO2) and Soxhlet (using hexane solvent) methods. The fatty acids and coumarins compound of the obtained tamanu oil were analyzed by gas chromatography–mass spectrometry (GC-MS). The antibacterial and anti-inflammatory activities were also investigated by the diffusion method and performed on the white mice ears (Swiss albino). Content of fatty acid in tamanu oil extracted using sCO2 (72.62 %) was higher than that using Soxhlet method. The compound of coumaron (2H-1-bezopyran-2-one, C9H6O2) was identified belonging the simple coumarin group and its content in the tamanu oil extracted using sCO2 was the highest (169.69 μg/g), 1.79 and 2.04 times as much as that using Soxhlet method and the commercial oil, respectively. Besides, the results of investigation of the antibacterial activity suggested that the tamanu oil extracted using sCO2 was able to against some of strains namely: Staphylococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213, methycilin-resistant S. aureus (MRSA) ATCC 43300, and Pseudomonas aeruginosa (P. aeruginosa) ATCC 277853. In term of the anti-inflammatory activity, the tamanu oil extracted using sCO2 was anti-inflammatory effectively with reducing flammatory: 21.41 – 25.39 % as for the thickness of mice ears and 33.88 – 39.40 % as for the weight of mice ears.
Highlights
Tamanu with scientific name of Calophyllum inophyllum L is widely dispersed throughout the tropics including: Thailand, Myanmar, Malaysia, South India, Sri Lanka, Melanesia, and Polynesia
The tamanu oil extracted using supercritical CO2 has the total content of omega (3, 6, and 9) of 72.62%, being higher than that of tamanu oil extracted by Soxhlet (71.18%) and the commercial oil (71.38%)
The antibacterial and anti-inflammatory activities of tamanu oil extracted by supercritical CO2 (sCO2) were compared with those of by Soxhlet method and commercial oil
Summary
Tamanu with scientific name of Calophyllum inophyllum L is widely dispersed throughout the tropics including: Thailand, Myanmar, Malaysia, South India, Sri Lanka, Melanesia, and Polynesia. The extracted tamanu oil has high amount of many actives like: calophyllic acid and lactone with the antibacterial, anti-inflammatory activities, and promote healing the scars. Omega is a mixture of essential fatty acids, it is one of the most important compositions in tamanu oil helping to treat various skin injuries, cell regeneration. It plays an important role in cosmetic, omega usually includes 3 main categories [7,8]:. Tamanu seeds were dried to a certain humidity before being entered the presses This method is simple and convenient, the crude tamanu oil is not pure and content of oil is not high. The antibacterial property was investigated using the diffusion method on agar plate and investigation of anti-inflammatory was performed on ear skin of white mice
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