Abstract
The present study was performed to identify the major chemical constituents in the fruits of Kigelia Africana. Six chemicals were isolated by silica gel and Sephadex LH-20 column chromatography and identified by ESI-MS and 1D-NMR as β-sitosterol (1), ferulic acid (2), caffeic acid (3), gallic acid (4), luteolin (5), and luteolin-7-O-β-D-glycopyranoside (6). Compounds 3 and 4 exhibited DPPH (1,1-diphenyl-2-picrylhydrazyl radical) free radical scavenging activity with IC50 values of 19.17 ± 1.01 and 10.24 ± 0.18 μM, respectively. Compound 4 had a moderate antioxidant effect with an IC50 value of 29.17 ± 1.64 μM versus DCHF-DA (dichloro-dihydro-fluorescein diacetate)-induced intracellular ROS generation. Compound 3 inhibited mushroom tyrosinase with an IC50 value of 39.91 ± 1.82 μM, and compound 5 dose-dependently induced the apoptosis of HCT116 human colorectal cancer cells.
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